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Effects of Midodrine Hydrochloride on Blood Pressure and Cerebral Blood Flow During Orthostasis in Persons With Chronic Tetraplegia  Jill M. Wecht, EdD,

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Presentation on theme: "Effects of Midodrine Hydrochloride on Blood Pressure and Cerebral Blood Flow During Orthostasis in Persons With Chronic Tetraplegia  Jill M. Wecht, EdD,"— Presentation transcript:

1 Effects of Midodrine Hydrochloride on Blood Pressure and Cerebral Blood Flow During Orthostasis in Persons With Chronic Tetraplegia  Jill M. Wecht, EdD, Dwindally Rosado-Rivera, EdD, John P. Handrakis, PT, EdD, Miroslav Radulovic, MD, William A. Bauman, MD  Archives of Physical Medicine and Rehabilitation  Volume 91, Issue 9, Pages (September 2010) DOI: /j.apmr Copyright © 2010 American Congress of Rehabilitation Medicine Terms and Conditions

2 Fig 1 The timeline for study procedures. The thin arrows represent data collection time points; the thick arrow represents midodrine administration. Archives of Physical Medicine and Rehabilitation  , DOI: ( /j.apmr ) Copyright © 2010 American Congress of Rehabilitation Medicine Terms and Conditions

3 Fig 2 The response to study visit: control (open circles), 5mg (closed triangles) and 10mg (closed squares), and condition (bl, postdrug, transition, HUT) for MAP (A, mmHg), heart rate (B, bpm) and MFV (C, cm/s). There were significant condition main effects for MAP, heart rate, and MFV (P<.0001), and the interaction effect was significant for MAP (P<.01) and MFV (P<.05). The main effect for study visit was not significant for MAP, heart rate, or MFV. NOTE. The letters a, b, c, d are 4 time points of data collection at 45° HUT. Abbreviation: bl, baseline. Archives of Physical Medicine and Rehabilitation  , DOI: ( /j.apmr ) Copyright © 2010 American Congress of Rehabilitation Medicine Terms and Conditions

4 Fig 3 The mean change from baseline in MAP (A), heart rate (B), and MFV (C) after no drug (white bars), 5mg midodrine (checked bars), and 10mg midodrine (black bars). *P<.05 versus no drug. Archives of Physical Medicine and Rehabilitation  , DOI: ( /j.apmr ) Copyright © 2010 American Congress of Rehabilitation Medicine Terms and Conditions

5 Fig 4 Individual MAP responses to no drug, 5mg midodrine, and 10mg midodrine during the supine postdrug/no drug period (A) and during the sustained HUT maneuver at 45° (B). Archives of Physical Medicine and Rehabilitation  , DOI: ( /j.apmr ) Copyright © 2010 American Congress of Rehabilitation Medicine Terms and Conditions


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