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Gregory A. Hawkins, PhD, Mac B. Robinson, PhD, Annette T

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Presentation on theme: "Gregory A. Hawkins, PhD, Mac B. Robinson, PhD, Annette T"— Presentation transcript:

1 The IL6R variation Asp358Ala is a potential modifier of lung function in subjects with asthma 
Gregory A. Hawkins, PhD, Mac B. Robinson, PhD, Annette T. Hastie, PhD, Xingnan Li, PhD, Huashi Li, MS, Wendy C. Moore, MD, Timothy D. Howard, PhD, William W. Busse, MD, Serpil C. Erzurum, MD, Sally E. Wenzel, MD, Stephen P. Peters, MD, PhD, Deborah A. Meyers, PhD, Eugene R. Bleecker, MD  Journal of Allergy and Clinical Immunology  Volume 130, Issue 2, Pages e1 (August 2012) DOI: /j.jaci Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Frequency of subjects homozygous for the IL6R Ala358 allele in SARP phenotypic asthma clusters. Genotypic analysis was performed for 355 subjects of European ancestry with asthma. Journal of Allergy and Clinical Immunology  , e1DOI: ( /j.jaci ) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Evaluation of serum sIL-6R levels in SARP subjects with asthma. A, Association of the IL6R coding SNP rs (Asp358Ala) with serum sIL-6R levels. B, Serum sIL-6R versus percent predicted FEV1. C, Serum sIL-6R levels versus percent predicted FVC. sIL-6R analyses were performed from sera collected from 146 subjects of European ancestry. Journal of Allergy and Clinical Immunology  , e1DOI: ( /j.jaci ) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Representative immunostaining of an endobronchial biopsy specimen and BAL cells with anti–IL-6Ra in subjects with asthma. A, Airway epithelium, smooth muscle, and vascular endothelium stained positive for IL-6Ra in the biopsy specimen. B, Predominantly macrophages stained positive for IL-6Ra in lavage samples, although some polymorphonucleated granulocytes showed lower amounts of IL-6Ra stain, as seen in the upper right. Journal of Allergy and Clinical Immunology  , e1DOI: ( /j.jaci ) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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