1. Baseline activity of the BCR signaling gene module (M54) is associated with influenza vaccination responses in young individuals.
Baseline activity of the BCR signaling gene module (M54) is associated with influenza vaccination responses in young individuals. QuSAGE was used to calculate the PDF for the gene module activity using baseline data in the (A) discovery cohorts (SDY63, SDY404, SDY400, SDY212, and the combination) and (B) validation cohort (SDY80). (C) Temporal behavior of gene module in the validation cohort (SDY80) for low, moderate, and high responders. Each point depicts an individual participant, and each point group is summarized by a boxplot. Significant P values are indicated above the data for comparisons of low and high responders and below the data for comparison between baseline and day 1 after vaccination.
HIPC-CHI Signatures Project Team, and HIPC-I Consortium Sci. Immunol. 2017;2:eaal4656
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