1. SEVERELY IMPAIRED NUTRITIONAL STATUS IN PATIENTS WITH LOCALLY ADVANCED PANCREATIC CANCER
PAN-NUTRIENT STUDY
Drs. CM Lochtenberg–Potjes, JE Witvliet MSc, Dr. MAE De van der Schueren, H. Öztürk MSc 1

2. Introduction Pancreatic carcinoma is aggressive!
80% of patients already locally advanced of which 50% with evidence of metastases
The carcinoma affects:
Nutritional status
Gastrointestinal functioning
Caused by:
Exocrine insufficiency
Metabolic changes
Objective:
Provide quantitative data on nutritional and gastrointestinal aspects

3. Methods Patients Nutritional Assessment:
Included in PANFIRE study
Nutritional Assessment:
BMI and weight changes
Energy intake (4-d food diary)
Resting Energy Expenditure (REE)
Hand grip strength
Fat Free Mass Index (FFMI)
Gastro-intestinal functioning:
Energy intake (4-d food diary) and energy loss (3-d feces analysis)

4. BMI does not seem to reflect nutritional status sufficiently in LAPC Patients

5. Energy intake seems sufficient compared to equations, but equations underestimate actual energy needs by 30% in Lapc patients
Figure 1: Median energy intake vs predicted (p) and measured (m) Total Energy Expenditure (TEE), kcal/day

6. individual energy absorption capacity ranges from not impaired to severely impaired in lapc patients
Moderately impaired
Severely impaired No
data
LAPC patient number
Figure 2: Absorption capacity (%) of individual patients vs not impaired, moderately and severely impaired

7. conclusions In patients with LAPC
BMI does not seem to reflect nutritional status sufficiently
Nutritional intake seems sufficient if compared to energy requirement equations, but these equations underestimate actual, measured energy needs by 30%
Individual energy absorption capacity ranges from severely impaired to not impaired at all