1. The “Aspirin” of the New Millennium: Cyclooxygenase-2 Inhibitors
Navtej S. Buttar, MBBS, Kenneth K. Wang, MD 
Mayo Clinic Proceedings 
Volume 75, Issue 10, Pages (October 2000)
DOI: /
Copyright © 2000 Mayo Foundation for Medical Education and Research Terms and Conditions

2. Figure 1
Pathologic and biologic functions of cyclooxygenase (COX)-2. Expression of COX-2 is restricted under basal conditions, but it can be induced substantially during inflammation, repair, and neoplasia. COX-l is expressed constitutively and maintains normal physiologic functions of the cells in most tissues, but in a few situations, COX-l may also be induced. Both isoforms convert arachidonic acid to prostaglandin (PO) H2. Depending on the site and circumstances of expression, the final PO product may vary. On a scale of 1+ to 3+ in which 1+ is minimal and 3+ is maximal. TX = thromboxane.
Mayo Clinic Proceedings  , DOI: ( / )
Copyright © 2000 Mayo Foundation for Medical Education and Research Terms and Conditions

3. Figure 2
Potential role of cycIooxygenase (COX)-2 in carcinogenesis. Induction of COX-2 in neoplastic tissue can potentially promote carcinogenesis by modifying prostaglandin profile, immune response, and carcinogen metabolism.
Mayo Clinic Proceedings  , DOI: ( / )
Copyright © 2000 Mayo Foundation for Medical Education and Research Terms and Conditions