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A Titrated Morphine Analgesic Regimen Comparing Substance Users and Non-Users with AIDS-Related Pain  Ronald Kaplan, MD, Joseph Slywka, PhD, Susan Slagle,

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Presentation on theme: "A Titrated Morphine Analgesic Regimen Comparing Substance Users and Non-Users with AIDS-Related Pain  Ronald Kaplan, MD, Joseph Slywka, PhD, Susan Slagle,"— Presentation transcript:

1 A Titrated Morphine Analgesic Regimen Comparing Substance Users and Non-Users with AIDS-Related Pain 
Ronald Kaplan, MD, Joseph Slywka, PhD, Susan Slagle, MPH, Kristen Ries, MD  Journal of Pain and Symptom Management  Volume 19, Issue 4, Pages (April 2000) DOI: /S (00)

2 Fig. 1 Mean daily pain intensity for baseline and end of study. *Statistically significant reduction in pain (P ≤ ). No significant differences were found between DU and NU. Pain intensity: 0 = none, 1 = mild, 2 = moderate, 3 = severe, 4 = overwhelming Journal of Pain and Symptom Management  , DOI: ( /S (00) )

3 Fig. 2 Total daily morphine requirements (intent-to-treat patients). #Significant interaction (P = ). DU and NU had significant increase in dose (P ≤ ). DU were significantly higher than NU during the final 3 days (P = ). *Significant reduction in IRM (P = ). Significant difference between DU and NU (P = interaction (P = ). DU required more morphine both initial (P = ) and final (P = ); DU showed significant increase over time (P = 0.040) Journal of Pain and Symptom Management  , DOI: ( /S (00) )

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