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How Much Longer Will We Put Up With $100,000 Cancer Drugs?

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Presentation on theme: "How Much Longer Will We Put Up With $100,000 Cancer Drugs?"— Presentation transcript:

1 How Much Longer Will We Put Up With $100,000 Cancer Drugs?
Paul Workman, Giulio F. Draetta, Jan H.M. Schellens, René Bernards  Cell  Volume 168, Issue 4, Pages (February 2017) DOI: /j.cell Copyright © 2017 Elsevier Inc. Terms and Conditions

2 Figure 1 The Academic Drug Discovery and Development Continuum and Its Relationships with Stakeholders Critical components of the cancer drug discovery and development process through commercialization are described. Through comprehensive integration of expertise, cancer biologists and geneticists, drug discovery scientists and pharmacologists are able to precisely formulate a Clinical Candidate Profile based on tumor subtype(s) and patient population that might best benefit from treatment. Project financing leverages philanthropic donations and partnerships with CROs and generic drug makers, allowing not-for profit entities to retain control from the start through commercialization. CRO, contract research organization, a provider of services to the biopharmaceutical industry; PD, pharmacodynamics, determines a drug mechanism of action and safety profile; generic drug maker, a high-volume, low profit margin organization devoted to the manufacturing and commercialization of drugs past their patent expiry; pharmaco-economics, a comprehensive evaluation of the impact of a given program on the health of a population, often leads to decisions on policies; response biomarker, a biological indicator predicting response to a given treatment. Cell  , DOI: ( /j.cell ) Copyright © 2017 Elsevier Inc. Terms and Conditions

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