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Chronic phenytoin increases activity levels in Mecp2Null/Y mice.

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Presentation on theme: "Chronic phenytoin increases activity levels in Mecp2Null/Y mice."— Presentation transcript:

1 Chronic phenytoin increases activity levels in Mecp2Null/Y mice.
Chronic phenytoin increases activity levels in Mecp2Null/Y mice. (A,B) Phenytoin treatment in Mecp2Null/Y mice caused increased activity levels in the open field but had no effect on Mecp2Null/+ mice. (C,D) No effects were observed on anxiety. (E,F) Motor learning was not improved with phenytoin treatment. (G,H) Mecp2Null/Y and Mecp2Null/+ mice had poor motor coordination as determined by an increase in foot slips in parallel rod. Data are expressed as means±s.e.m. n=6–11 per genotype per treatment unless otherwise stated. *P<0.05, ***P≤0.001; ^P<0.05 between genotypes; +P<0.05 for Mecp2Null/Y vehicle versus Mecp2Null/Y treated with phenytoin. José A. Herrera et al. Dis. Model. Mech. 2015;8: © Published by The Company of Biologists Ltd

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