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Fig. 2 Boronic acid–rich dendrimer in cytosolic delivery.

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Presentation on theme: "Fig. 2 Boronic acid–rich dendrimer in cytosolic delivery."— Presentation transcript:

1 Fig. 2 Boronic acid–rich dendrimer in cytosolic delivery.
Boronic acid–rich dendrimer in cytosolic delivery. (A) Cytosolic delivery of BSA-FITC into HeLa cells by P0 to P4 for 4 hours. The doses of protein and dendrimer in each well were 6 and 8 μg, respectively. (B) DLS analysis of P0, P1, P2, P3, and P4/BSA complexes, and TEM of P4/BSA nanoparticles. Scale bar, 200 nm. (C) Structure of the PBA analog materials. (D) Confocal images and (E) flow cytometry analysis of HeLa cells treated with P4/BSA-FITC or analog complexes of P5 to P8 for 4 hours. The doses of protein and dendrimer were 6 and 8 μg in each well, respectively. Commercial reagents PULSin and TransEx were used as positive controls. (F) DLS analysis of P4, P5, P6, P7, and P8/BSA-FITC complexes. (G) Time-dependent internalization of P4/BSA-FITC by HeLa cells. (H) Viability of HeLa cells treated with P4/BSA, P4, and BSA complexes. The concentrations of materials were equal to those in cytosolic protein delivery. Chongyi Liu et al. Sci Adv 2019;5:eaaw8922 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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