1. Volume 35, Issue 6, Pages 845-846 (December 2011)
T Cell Myc-tabolism 
Jeffrey C. Rathmell 
Immunity 
Volume 35, Issue 6, Pages (December 2011)
DOI: /j.immuni
Copyright © 2011 Elsevier Inc. Terms and Conditions

2. Figure 1
Regulatory Mechanisms that Control T Cell Metabolic Reprogramming in Activation
T cell activation leads to increased glucose, glutamine, and mitochondrial oxidative metabolism that are essential for cell growth and proliferation. Data presented by Wang et al. (2011) shows Myc plays a key role in upregulation of glucose, glutamine, and polyamine metabolism. In addition, the Akt-mTOR pathway promotes posttranslational events in aerobic glycolysis, and ERRα may play a role in regulating mitochondrial metabolism in T cell activation.
Immunity  , DOI: ( /j.immuni )
Copyright © 2011 Elsevier Inc. Terms and Conditions