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Cat IgA, representative of new carbohydrate cross-reactive allergens

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Presentation on theme: "Cat IgA, representative of new carbohydrate cross-reactive allergens"— Presentation transcript:

1 Cat IgA, representative of new carbohydrate cross-reactive allergens
Justus Adédoyin, MSc, Hans Grönlund, PhD, Hans Öman, PhD, S.G.O. Johansson, MD, PhD, Marianne van Hage, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 119, Issue 3, Pages (March 2007) DOI: /j.jaci Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Analyses of size and purity of purified cat immunoglobulins by Coomassie blue stained 15% SDS-PAGE under reducing conditions. Lane 1, low molecular weights markers; lane 2, IgA; lane 3, PNGase F treated IgA; lane 4, IgM. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Correlation between IgE reactivity to cat IgA (y-axis) and cat dander extract (x-axis) among 21 cat-sensitized patients using the Pharmacia CAP System (r = 0.02; P > .05). Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 IgE reactivity to natural cat IgA and deglycosylated cat IgA shown as OD values in 21 cat IgA CAP–positive sera (solid circles) and OD values for goat anticat IgA (positive control, crosses). Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 4 Correlation between IgE reactivity to cat IgA (y-axis) and cat IgM (x-axis) among 21 cat IgA–sensitized patients using ELISA (r = 0.93; P < .001). Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Fig 5 Competition of IgE responses to cat IgA in 9 cat-sensitized patients using ELISA. Y-axis, OD after preincubation with buffer, recombinant Fel d 1, CSA, CIP, IgM, and IgA. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

7 Fig 6 Goat anticat immunoglobulin light chains (lane 1) and goat anticat IgA α-chains (lane 2), IgE reactivity of patients' sera (lane 3-7) to PVDF blotted cat IgA (A). Cat IgA α-chain recognition in 3 different batches of cat dander extract without (lanes 1, 3, and 5) and with (lanes 2, 4, and 6) preincubation with cat IgA (B). IgE reactivity to cat IgA (lane 1) and deglycosylated IgA (lane 2) in a pool of 21 cat IgA–sensitized patients, for control purpose, goat antibodies to cat IgA α-chains on cat IgA (lane 3), and deglycosylated cat IgA (lane 4)(C). Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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