1. Suggested model of integrated regulation of CCL2 by miRNAs and TFs in human adipocytes and macrophages.
Suggested model of integrated regulation of CCL2 by miRNAs and TFs in human adipocytes and macrophages. The validated transcriptional regulatory subnetwork including three miRNAs (miR-126, -193b, and -92a; □), three TFs (MAX, ETS1, and SP1; ○), and an NF-κB subnetwork all directly or indirectly regulating the expression and secretion of CCL2 (♦) from the adipose tissue in obesity (upper part). In the lower part of the model, miRNAs (miR-126 and -193b; □) and possible TF network (○) regulating CCL2 production in macrophages are presented. T-bars represent inhibition, and arrows represent stimulation. Bold edges represent interactions between nodes described in this and previous studies in adipocytes, and thin lines are predicted by network analyses or shown in other cells types. Dashed edges/lines in the lower part represent possible interactions.
Agné Kulyté et al. Diabetes 2014;63:
©2014 by American Diabetes Association