1. Effects of interleukin-1 receptor antagonist (IL-1Ra) on peripheral blood mononuclear cell (PBMC) responses to non-typeable Haemophilus influenzae (NTHi).
Effects of interleukin-1 receptor antagonist (IL-1Ra) on peripheral blood mononuclear cell (PBMC) responses to non-typeable Haemophilus influenzae (NTHi). PBMCs were cultured ex vivo with NTHi in the presence or absence of the IL-1Ra anakinra. Data are from 14–15 healthy control children, 17–19 children with protracted bacterial bronchitis (PBB) and 12–13 children with bronchiectasis (BE). a) Interleukin (IL)-1β concentration. b) IL-6 concentration. c) IL-18 concentration. d) IFN-γ concentration. e) IL-10 concentration. ns: nonsignificant. *: p<0.05 by Wilcoxon matched-pairs signed rank test; **: p<0.01 by Wilcoxon matched-pairs signed rank test; ***: p<0.001 by Wilcoxon matched-pairs signed rank test.
Alice C-H. Chen et al. ERJ Open Res 2017;3:
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