1. Improved fitting with VFO.
Improved fitting with VFO. (A) Flow diagram showing how VFO is integrated into the fitting procedure. The resulting parameter set is used to initialize one particle and to pre-emphasize kinetic parameters. (B) Score for fits to circadian transcription data from mouse liver and SCN with and without VFO. Each point represents a fitted model. VFO leads to significantly lower score values (Wilcoxon rank–sum test, P-value liver: 4.29 × 10−7, P-value SCN: × 10−6).
J Patrick Pett et al. LSA 2018;1:e
© 2018 Pett et al.