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Figure 1. MBP-specific IFN-γ+ but not IL-17+ frequencies are significantly different between patients with MS and HCs MBP-specific IFN-γ+ but not IL-17+

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Presentation on theme: "Figure 1. MBP-specific IFN-γ+ but not IL-17+ frequencies are significantly different between patients with MS and HCs MBP-specific IFN-γ+ but not IL-17+"— Presentation transcript:

1 Figure 1. MBP-specific IFN-γ+ but not IL-17+ frequencies are significantly different between patients with MS and HCs MBP-specific IFN-γ+ but not IL-17+ frequencies are significantly different between patients with MS and HCs PBMCs from HCs (n = 45), brain-predominant (n = 29) and spinal cord–predominant (n = 16) patients with MS were analyzed for (A) IFN-γ or (B) IL-17 MBP-specific responses by enzyme-linked immunosorbent spot. (C) The ratio of Th17:Th1 cells was calculated for each subject and plotted on a log2 axis. If the denominator (Th1) was 0, the value was changed to based on the lowest possible calculated spot number being 1 spot above background/triplicate wells. *p < 0.05, **p < 0.01, ***p < 0.001, Mann–Whitney test, 2-sided. HC = healthy control; IFN = interferon; IL = interleukin; MBP = myelin basic protein; MS = multiple sclerosis; PBMCs = peripheral blood mononuclear cells; SC = spinal cord. Mark C. Johnson et al. Neurol Neuroimmunol Neuroinflamm 2016;3:e278 © 2016 American Academy of Neurology

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