1. Pseudopheochromocytoma Secondary to Brimonidine Ophthalmic Solution
Gagangeet Sandhu, MD, Antony A. Farias, MD, Richard Ames, MD 
The American Journal of Medicine 
Volume 123, Issue 5, Pages e7-e8 (May 2010)
DOI: /j.amjmed
Copyright © 2010 Elsevier Inc. Terms and Conditions

2. Figure 1
A 24-hour ambulatory blood pressure summary: Sixty-six blood pressure readings were obtained for this patient in a 50-hour period. It was noted that 76% of all the systolic and 45% of the diastolic blood pressure measurements exceeded the threshold (of 140/90 mm Hg while awake and 120/80 while asleep). Brimonidine dosing was at approximately 9 am and 9 pm daily (↓). Hypotensive episodes occurred approximately 1 hour after dosing and were associated with symptoms of dizziness. Severe rebound hypertension followed later, with signs and symptoms mimicking pheochromocytoma. Urine catecholamines and metanephrines were normal. Signs and symptoms resolved after discontinuation of brimonidine. ABP=ambulatory blood pressure.
The American Journal of Medicine  , e7-e8DOI: ( /j.amjmed )
Copyright © 2010 Elsevier Inc. Terms and Conditions