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Effects of delta-9-tetrahydrocannabinol, the primary psychoactive cannabinoid in marijuana, on human sperm function in vitro  Lynne B. Whan, Ph.D., Mhairi.

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Presentation on theme: "Effects of delta-9-tetrahydrocannabinol, the primary psychoactive cannabinoid in marijuana, on human sperm function in vitro  Lynne B. Whan, Ph.D., Mhairi."— Presentation transcript:

1 Effects of delta-9-tetrahydrocannabinol, the primary psychoactive cannabinoid in marijuana, on human sperm function in vitro  Lynne B. Whan, Ph.D., Mhairi C.L. West, Ph.D., Neil McClure, M.R.C.O.G., Sheena E.M. Lewis, Ph.D.  Fertility and Sterility  Volume 85, Issue 3, Pages (March 2006) DOI: /j.fertnstert Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

2 FIGURE 1 (A) Effect of THC, at recreational and therapeutic concentrations, on the numbers of progressively motile sperm in the 90% fraction. (B) Effect of THC, at recreational and therapeutic concentrations, on the numbers of progressively motile sperm in the 45% fraction. Black bar = control; yellow bar = μM; red bar = 0.32 μM; blue bar = 4.8 μM THC. Whan. Cannabis and sperm function. Fertil Steril 2006. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

3 FIGURE 2 Effect of THC, at the higher therapeutic concentration, on the quality of sperm motility (VAP and VSL) in the 90% fraction. Black bar = control; blue bar = 4.8 μM THC. Whan. Cannabis and sperm function. Fertil Steril 2006. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

4 FIGURE 3 (A) Effect of THC, at recreational and therapeutic concentrations, on the acrosome reaction of sperm in the 90% fraction. (B) Effect of THC, at recreational and therapeutic concentrations, on the acrosome reaction of sperm in the 45% fraction. Black bar = control; yellow bar = μM; red bar = 0.32 μM; blue bar = 4.8 μM THC. Whan. Cannabis and sperm function. Fertil Steril 2006. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

5 FIGURE 4 Effect of THC, at the higher recreational concentration, on the artificially induced acrosome reaction of sperm in the 90% fraction. Whan. Cannabis and sperm function. Fertil Steril 2006. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions


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