1. Long-term attenuation of FGFR2b signaling in adult mice causes loss of maxillary incisors.
Long-term attenuation of FGFR2b signaling in adult mice causes loss of maxillary incisors. (A) Timecourse for postnatal doxycycline treatment. (B-I′) Whole-mount images of control (B-E′) and DTG (F-I′) mice after 14 (B,F), 28 (C,G), 56 (D,H) and 76 (E,E′,I,I′) days of doxycyline treatment. (J) Diagram of the region analyzed by microCT. Blue represents mesenchyme and dark brown represents epithelium. (K-L′) MicroCT analysis showing enamel and bone (K,L) or enamel only (K′,L′). Green line and pink line indicate enamel in the maxillary and mandibular incisor, respectively. Dotted yellow lines indicate the absence of enamel in the proximal regions of the DTG incisors. Di, distal; laCL, labial cervical loop; liCL, lingual cervical loop; M, molars; P, postnatal day; Pr, proximal.
Sara Parsa et al. Development 2010;137:
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