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Histological and immunohistochemical evaluation of postmenopausal endometrium after 3 weeks of treatment with tibolone, estrogen only, or estrogen plus.

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Presentation on theme: "Histological and immunohistochemical evaluation of postmenopausal endometrium after 3 weeks of treatment with tibolone, estrogen only, or estrogen plus."— Presentation transcript:

1 Histological and immunohistochemical evaluation of postmenopausal endometrium after 3 weeks of treatment with tibolone, estrogen only, or estrogen plus progestagen  Anet H.A. Klaassens, M.D., F. Heidy van Wijk, M.D., Payman Hanifi-Moghaddam, Ph.D., Bianca Sijmons, B.Sc., Patricia C. Ewing, M.D., Ph.D., Marian J. Ten Kate-Booij, M.D., Ph.D., G. Sjarlot Kooi, M.D., Ph.D., Helenius J. Kloosterboer, Ph.D., Leen J. Blok, Ph.D., Curt W. Burger, M.D., Ph.D.  Fertility and Sterility  Volume 86, Issue 2, Pages (August 2006) DOI: /j.fertnstert Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

2 FIGURE 1 Overview of the evaluation of endometrial morphology. Two magnifications are presented (×200 and ×400). The activity of the endometria is indicated in the left-hand images. More detailed changes in the endometrial glands are indicated in the right-hand images. In the estrogen+progestagen treatment group, in some glands but not all, clear cell changes were observed as if cells were filled with secretory vesicles, but were unable to secrete. Klaassens. Tibolone and the human endometrium. Fertil Steril 2006. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

3 FIGURE 2 Quantified immunohistochemical scores from Table 2. In total, the following numbers of tissues from different treatment group patients were assessed: control, n = 6; tibolone, n = 5; estrogen only, n = 6; estrogen+progestagen (E2+MPA), n = 5. Values are presented as mean ± SE. aP<.05 in comparison with control group, Student’s t-test; bP<.05 in comparison with tibolone group, Student’s t-test. Klaassens. Tibolone and the human endometrium. Fertil Steril 2006. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

4 FIGURE 3 Immunohistochemical images from the different treatment groups. Representative images of all stainings and all treatment groups are presented. Magnification ×200. Klaassens. Tibolone and the human endometrium. Fertil Steril 2006. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions


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