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Journal of Allergy and Clinical Immunology

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1 Journal of Allergy and Clinical Immunology
Double-blind, placebo-controlled, randomized trial on low-dose azithromycin prophylaxis in patients with primary antibody deficiencies  Cinzia Milito, PhD, Federica Pulvirenti, PhD, Francesco Cinetto, PhD, Vassilios Lougaris, PhD, Annarosa Soresina, MD, Antonio Pecoraro, MD, Alessandra Vultaggio, PhD, Maria Carrabba, PhD, Giuseppe Lassandro, PhD, Alessandro Plebani, PhD, Giuseppe Spadaro, MD, Andrea Matucci, MD, Giovanna Fabio, MD, Rosa Maria Dellepiane, MD, Baldassarre Martire, MD, Carlo Agostini, PhD, Damiano Abeni, MD, Stefano Tabolli, MD, Isabella Quinti, PhD  Journal of Allergy and Clinical Immunology  DOI: /j.jaci Copyright © 2019 The Authors Terms and Conditions

2 Journal of Allergy and Clinical Immunology DOI: (10.1016/j.jaci.2019.01.051)
Copyright © 2019 The Authors Terms and Conditions

3 Fig 1 Trial profile. Journal of Allergy and Clinical Immunology DOI: ( /j.jaci ) Copyright © 2019 The Authors Terms and Conditions

4 Fig 2 Kaplan-Meier plot. A and B, Proportion of patients remaining exacerbation free during the study time in the intervention (red line) and control (blue line) groups in the study period (T1-T3; Fig 2, A) and run-out period (T3-T4; Fig 2, B). C and D, Proportion of participants free from hospital admission (Fig 2, C) and additional antibiotic courses (Fig 2, D) in the intervention (red line) and control (blue line) groups during the study period. Journal of Allergy and Clinical Immunology DOI: ( /j.jaci ) Copyright © 2019 The Authors Terms and Conditions

5 Fig 3 Absolute blood counts of WBCs, neutrophils, lymphocytes, and eosinophils over time in the treatment groups. Journal of Allergy and Clinical Immunology DOI: ( /j.jaci ) Copyright © 2019 The Authors Terms and Conditions

6 Fig 4 Pathogenic bacteria analysis. A and B, Number of positive isolates from sputum samples in the azithromycin (Fig 4, A) and placebo (Fig 4, B) groups. C, Proportion of S pneumoniae and H influenzae isolates not susceptible to macrolides in the intervention (red pie chart) and placebo (blue pie chart) groups. D, Time of the appearance of macrolide resistance. Journal of Allergy and Clinical Immunology DOI: ( /j.jaci ) Copyright © 2019 The Authors Terms and Conditions

7 Fig E1 IgG trough levels during the study period in the azithromycin (red line) and placebo (blue line) groups. Journal of Allergy and Clinical Immunology DOI: ( /j.jaci ) Copyright © 2019 The Authors Terms and Conditions

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