1. Effects of brief photostimulation on the breathing phase and inspiratory duration from Dbx1;CatCh mice (n = 4, cyan) and wild-type littermates (n = 4, magenta).
Effects of brief photostimulation on the breathing phase and inspiratory duration from Dbx1;CatCh mice (n = 4, cyan) and wild-type littermates (n = 4, magenta). A1, Phase-response curve plotting ΦShift following 100-ms photostimulation at ΦStim throughout the breathing cycle in sedated mice. ΦStim was partitioned into 12 equally sized bins (30°) in A, B. A2, Phase-response curve for changes in Ti following photostimulation (i.e., the perturbed breath) in the same cohort of sedated mice. The abscissa marks the inspiratory (I, 0–150°) and expiratory (E, 150–360°) phases of the breathing cycle (0–360°), which applies to A1, A2. A3, Sample airflow traces from a representative sedated mouse (ΦStim is indicated by an orange bar and numeral value). Time calibration as shown. B1, Phase-response curve plotting ΦShift following brief photostimulation at ΦStim throughout the breathing cycle in awake unrestrained mice. B2, Phase-response curve for changes in Ti following brief photostimulation (i.e., the perturbed breath) in the same cohort of awake unrestrained mice. The abscissa marks the inspiratory (I, 0–110°) and expiratory (E, 110–360°) phases of the complete breathing cycle (0–360°), which applies to B1, B2. B3, Sample airflow traces from a representative awake unrestrained mouse (ΦStim is indicated by an orange bar and numeral value). Time calibration is shown.
Nikolas C. Vann et al. eNeuro 2018;5:ENEURO
©2018 by Society for Neuroscience