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The new kid on the block(ade) of the IGF-1 receptor

Published byJean-Luc Mélançon Modified over 5 years ago

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Presentation on theme: "The new kid on the block(ade) of the IGF-1 receptor"— Presentation transcript:

1 The new kid on the block(ade) of the IGF-1 receptor
Derek LeRoith, Lee Helman  Cancer Cell  Volume 5, Issue 3, Pages (March 2004) DOI: /S (04)

2 Figure 1 Schematic of the IGF system
Extracellular IGFs bind to the IGF-1R and the activated tyrosine kinase leads to enhanced cell proliferation and cell survival mediated by signaling pathways that include the PI3′ kinase/Akt and the MAPK pathways. Inhibition of the IGF-1R may occur at multiple levels both extracellular and intracellular. Cancer Cell 2004 5, DOI: ( /S (04) )

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