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Expression of transgenic IGF-1Ea propeptide in the skin increases local Treg cell numbers. Expression of transgenic IGF-1Ea propeptide in the skin increases.

Published byἈσκληπιάδης Βασιλείου Modified over 5 years ago

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Presentation on theme: "Expression of transgenic IGF-1Ea propeptide in the skin increases local Treg cell numbers. Expression of transgenic IGF-1Ea propeptide in the skin increases."— Presentation transcript:

1 Expression of transgenic IGF-1Ea propeptide in the skin increases local Treg cell numbers.
Expression of transgenic IGF-1Ea propeptide in the skin increases local Treg cell numbers. (A) Relative levels of mRNA expression of Foxp3 and IL-10 in CD4+ CD3+ CD45+ lymphocytes isolated from the skin of wild-type and K14/IGF-1Ea mice 48 hours after CHS treatment. Relative expression values were normalized to the expression of the housekeeping gene hprt. (B) Flow cytometric analysis of T cell populations: percentages of T cells (CD3+ among total CD45+ immune cells), CD4+ T cells (CD4+ among CD3+ T cells) and Treg cells (Foxp3+ among CD4+ cells) in the skin of wild-type and K14/IGF-1Ea mice 48 hours after contact CHS treatment. (C) Flow cytometric analysis of CD3+, CD4+ and Treg cell populations (CD3+ among total CD45+ immune cells, CD4+ among CD3+ T cells, and CD25+CD127low among CD4+ cells) in the skin and spleen of unchallenged K14/IGF-1Ea mice and wild-type controls. *P<0.05. Bjarki Johannesson et al. Dis. Model. Mech. 2014;7: © Published by The Company of Biologists Ltd

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