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Combined Pan-HER and ALK/ROS1/MET Inhibition with Dacomitinib and Crizotinib in Advanced Non–Small Cell Lung Cancer: Results of a Phase I Study  Pasi.

Published byBranden Nicholson Modified over 5 years ago

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Presentation on theme: "Combined Pan-HER and ALK/ROS1/MET Inhibition with Dacomitinib and Crizotinib in Advanced Non–Small Cell Lung Cancer: Results of a Phase I Study  Pasi."— Presentation transcript:

1 Combined Pan-HER and ALK/ROS1/MET Inhibition with Dacomitinib and Crizotinib in Advanced Non–Small Cell Lung Cancer: Results of a Phase I Study  Pasi A. Jänne, MD, PhD, Alice T. Shaw, MD, PhD, D. Ross Camidge, MD, PhD, Giuseppe Giaccone, MD, PhD, S. Martin Shreeve, MD, PhD, Yiyun Tang, PhD, Zelanna Goldberg, MD, Jean-François Martini, PhD, Huiping Xu, PhD, Leonard P. James, MD, PhD, Benjamin J. Solomon, M.B.B.S., PhD  Journal of Thoracic Oncology  Volume 11, Issue 5, Pages (May 2016) DOI: /j.jtho Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

2 Figure 1 Best percentage change from baseline in target lesion size by patient in expansion cohort 1 (A) and expansion cohort 2 (B). On the basis of the response-evaluable population, excluding patients with early death, indeterminate response, or nonmeasurable disease. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

3 Figure 2 Plasma concentrations of soluble mesenchymal-epithelial transition factor in individual patients over time in expansion cohort 1 (A) and expansion cohort 2 (B). C, cycle; D, day. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

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