1. Effects of growth hormone and insulin-like growth factor 1 on progesterone production in human luteinized granulosa cells 
Toshiaki Taketani, M.D., Yoshiaki Yamagata, M.D., Ph.D., Akihisa Takasaki, M.D., Ph.D., Aki Matsuoka, M.D., Ph.D., Hiroshi Tamura, M.D., Ph.D., Norihiro Sugino, M.D., Ph.D. 
Fertility and Sterility 
Volume 90, Issue 3, Pages (September 2008)
DOI: /j.fertnstert
Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

2. Figure 1
Correlation between urinary growth hormone (GH) concentrations and (A) serum progesterone concentrations or (B) serum estradiol concentrations. Urine was collected for 24 hours during the midluteal phase, and urinary GH concentrations were measured. The GH concentrations in the urine were corrected by the urinary creatinine value, and serum progesterone (P4) and estradiol (E2) concentrations were measured on the same day as the urine was collected. Urinary GH was statistically significantly correlated with serum progesterone (y = 0.628x , R2 = 0.325, P<.05), and serum estradiol (y = x , R2 = 0.256, P<.05).
Fertility and Sterility  , DOI: ( /j.fertnstert )
Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

3. Figure 2
Dose-dependent effects of insulin-like growth factor 1 (IGF-1) and synergistic effects of IGF-1 and human chorionic gonadotropin (hCG) on progesterone production by luteinized granulosa cells. (A) Cells incubated with various concentrations of IGF-1 (1, 10, 100 ng/mL) for 24 hours. (B) Cells incubated with IGF-1 (100 ng/mL) in the presence or absence of hCG (1 IU/mL) for 24 hours. Data are expressed as a percentage of the control value in each incubation. Each bar represents the mean ± SEM of three different incubations. Different letters indicate statistically significant differences between groups (P<.05). The simple linear regression test between IGF-1 concentrations and progesterone production showed a statistically significant correlation (y = 0.345x , R2 = 0.578, P<.01), suggesting the dose-dependent effect of IGF-1 on progesterone production.
Fertility and Sterility  , DOI: ( /j.fertnstert )
Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions