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Cellular Division: Mitosis
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Mitosis: Division of the nucleus to:
1) Grow (SA:V) 2) Reproduce (asexual reproduction) 3) Repair damage replace worn cells IN all of these cases mitosis is followed by Cytokinesis (Division of cytoplasm)
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1) Cell Growth Cell size limited by SA:V ratio.
As cell grows SA increases… slower than volume SA/V……20/20 = 1 … /8000=.05 Small SA limits how fast oxygen can get in & How fast waste can get out Cell must divide because smaller cells have a Larger SA:V ratio = more SA per V
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2) Asexual Reproduction
A) Single celled organisms reproduce by splitting in ½ This type of mitosis is called binary fission B) multicellular organisms do asexual reproduction by budding
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3)Repair damage & Replace old cells
Heal wounds Replace skin Replace red blood cells
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4) Cell Cycle A) Interphase = between cell divisions 1) G1 = gap 1
a) cell grows b) cell does its job in the body 2) S = synthesis a) DNA replication b) each chromosome goes from 1 molecule -> 2 molecules c) become X-shaped
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d) chromosome is not supercoiled so =
chromatin (1-4 in diagram)
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3) G2 = gap 2 a) get ready to divide
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B) Prophase = first phase 1) chromosomes condense into chromatids 2) nuclear envelope breaks down 3) nucleoli disappear 4) spindle fibers form (microtubules)
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C) Metaphase 1) chromosomes line up single file at equator
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D) Anaphase 1) centromere breaks 2) sister chromatids move to opposite poles
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E. Telophase 1) chromatids reach poles 2) spindle fibers break down 3) nuclear envelope reforms 4) chromosomes decondense into chromatin
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F. Cytokinesis 1) dividing up cytoplasm 2) plants form cell plate a) grow new cell wall between nuclei 3) Animals form cleavage furrow b) microfibers of cell cortex constrict c) pinch cell in ½
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3 main parts to cell cycle
1) Interphase 2) Mitosis – nuclear division PMAT 3) Cytokinesis – dividing cytoplasm may not happen at all may start during telophase of mitosis
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New Cells formed by Mitosis
1) are identical clones (sister chromatids have identical DNA) 2) are called daughter cells 3) are diploid a) 2 of each type of C b) 1 from Mom & 1 from Dad
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4) notation for chromosome number is n a) n represents # different C
b) in the figure above n= 2 c) in the 2nd figure n=
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5) Humans n = 23 a) 22 different normal C: autosomes b) 1 sex chromosome pair XX = female Xy = male 6) 2n = diploid cell with 2 of each 7) 1n = haploid cell with only one of each type of C
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