1. Glued function is required to position Bolwig organ nuclei, where it is antagonized by kinesin heavy chain.
Glued function is required to position Bolwig organ nuclei, where it is antagonized by kinesin heavy chain. Wild-type second instar eye-antennal discs stained with anti-Elav show no neuronal nuclei in the eye-antennal disc along the path of the Bolwig nerve (A), while animals expressing dominant-negative Glued in postmitotic Bolwig photoreceptor neurons, using either the Elav promoter (B) or Glass38-1 (C), have neuronal nuclei (arrowheads in B,C) along the path of the Bolwig nerve (in C, anti-Chaoptin in red, anti-Elav in blue, arrow indicates Bolwig nerve). Misplaced Bolwig nuclei in animals that express dominant-negative Glued under Glass38-1 control were quantified in D. The number of misplaced Bolwig neuron nuclei was reduced when animals were heterozygous for loss-of-function mutations in khc. *P<0.05.
Jessica L. Whited et al. Development 2004;131:
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