1. Diagrammatic representation of thrombopoiesis in vivo.
Diagrammatic representation of thrombopoiesis in vivo. (A) Non-protruding megakaryocyte with intact peripheral zone and densely packed IMS. (B) Loss of peripheral zone allows IMS to fuse with plasma membrane and a protrusion to form, which anchors to the luminal surface of the endothelium. (C) IMS trafficked along MTs continues to extrude into the protrusion plasma membrane resulting in extension into the sinusoid lumen in the direction of flow. After release of the large protrusion, MT and membrane reorganization must occur to form proplatelets and ultimately platelets.
Edward Brown et al. LSA 2018;1:e
© 2018 Brown et al.