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Circulating Bioactive and Immunoreactive Recombinant Human Follicle-Stimulating Hormone (Org 32489) After Administration to Gonadotropin-Deficient Subjects 

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Presentation on theme: "Circulating Bioactive and Immunoreactive Recombinant Human Follicle-Stimulating Hormone (Org 32489) After Administration to Gonadotropin-Deficient Subjects "— Presentation transcript:

1 Circulating Bioactive and Immunoreactive Recombinant Human Follicle-Stimulating Hormone (Org 32489) After Administration to Gonadotropin-Deficient Subjects  Tiina Matikainen, Renato De Leeuw, Bernadette Mannaerts, Ilpo Huhtaniemi  Fertility and Sterility  Volume 69, Issue 2, Pages 3S-9S (February 1998) DOI: /S (97)

2 Fig. 1 Dose-response characteristics of serially diluted recombinant FSH in rat granulosa cell bioassay (bioactive FSH) and immunofluorometric assay (immunoreactive FSH). The correlation coefficient above the detection limit of FSH bioassay was 1.00 (P < 0.001). The Fig. 1 is representative of one of three similar dose-response experiments. Fertility and Sterility  , 3S-9SDOI: ( /S (97) )

3 Fig. 2 Serum bioactive (upper panels) and immunoreactive (lower panels) FSH values (scatter plots) and medians (connected with lines) after intramuscular injection of 300 IU of recombinant (left panels) and urinary (right panels) human FSH in gonadotropin-deficient women (A) and men (B). The bioactive FSH values below detection limit are expressed as the detection limit. Fertility and Sterility  , 3S-9SDOI: ( /S (97) )

4 Fig. 3 The bioactive to immunoreactive ratios of FSH after 300 IU of recombinant human FSH (black bars; n = 8) and urinary human FSH (white bars; n = 8). ∗P < 0.05, ∗∗P < 0.01 versus after recombinant FSH treatment. Fertility and Sterility  , 3S-9SDOI: ( /S (97) )

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