1. Fibrosis in Fontan physiology
R. Erik Edens, MD, PhD, Peter J. Gruber, MD, PhD 
The Journal of Thoracic and Cardiovascular Surgery 
Volume 151, Issue 6, Pages (June 2016)
DOI: /j.jtcvs
Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

2. Figure 1
Structure of collagen. Procollagen is composed of 2 α1 chains and 1 α2 chain intertwined into a triple helix. Propeptide domains at the carboxy-terminal and amino-terminal ends are cleaved and released into the plasma.
(From Fan D, Takawale A, Lee J, Kassiri Z. Cardiac fibroblasts, fibrosis, and extracellular matrix remodeling in heart disease. Fibrogenesis Tissue Repair. 2012;5:15.)
The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs )
Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

3. The amino-terminal peptide domain of procollagen is cleaved and released into plasma.
The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs )
Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions