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Contaminants in Commercial Preparations of Melatonin

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1 Contaminants in Commercial Preparations of Melatonin
Brian L. Williamson, Ph.D., Andrew J. Tomlinson, Ph.D., Stephen Naylor, Ph.D., Gerald J. Gleich, M.D.  Mayo Clinic Proceedings  Volume 72, Issue 11, Pages (November 1997) DOI: /S (11) Copyright © 1997 Mayo Foundation for Medical Education and Research Terms and Conditions

2 Fig. 1 Chemical structures of contaminants detected in eosinophilia-myalgia syndrome (EMS)-associated L-tryptophan (L-Trp) and in commercial preparations of melatonin. “Peak E” contaminant from EMS-associated L-Trp (A). Formaldehyde-melatonin condensation product (B), structural isomers of hydroxymelatonin (C and D), and peak E analogue (E) detected in random samples of melatonin. Mayo Clinic Proceedings  , DOI: ( /S (11) ) Copyright © 1997 Mayo Foundation for Medical Education and Research Terms and Conditions


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