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Elevated serum melatonin is associated with the nocturnal worsening of asthma  E.Rand Sutherland, MD, MPH, Misoo C Ellison, PhD, Monica Kraft, MD, Richard.

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Presentation on theme: "Elevated serum melatonin is associated with the nocturnal worsening of asthma  E.Rand Sutherland, MD, MPH, Misoo C Ellison, PhD, Monica Kraft, MD, Richard."— Presentation transcript:

1 Elevated serum melatonin is associated with the nocturnal worsening of asthma 
E.Rand Sutherland, MD, MPH, Misoo C Ellison, PhD, Monica Kraft, MD, Richard J Martin, MD  Journal of Allergy and Clinical Immunology  Volume 112, Issue 3, Pages (September 2003) DOI: /S (03)

2 FIG 1 Twenty-four–hour pattern of melatonin levels in subjects with nocturnal asthma (green), non-nocturnal asthma (red), and in healthy controls (blue). Paired horizontal arrows indicate a phase delay in peak melatonin time in nocturnal asthma. ∗Nocturnal asthma > controls, P < .05. Journal of Allergy and Clinical Immunology  , DOI: ( /S (03) )

3 FIG 2 Correlation between peak serum melatonin level and overnight change in FEV1 in subjects with nocturnal asthma, non-nocturnal asthma, and in healthy controls. Journal of Allergy and Clinical Immunology  , DOI: ( /S (03) )

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