1. Satellite cell fate decisions.
Satellite cell fate decisions. Activated satellite stem cells (Pax7+, Myf5–, MyoD–) can undergo symmetric divisions to expand the satellite stem cell population, or asymmetric divisions to maintain the stem cell population and generate myogenic progenitors. Satellite cells can also commit to the myogenic lineage and proliferate to give rise to committed myogenic progenitors (Pax7+, Myf5+ and/or MyoD+). Myogenic progenitors are able to asymmetrically divide or directly differentiate into myocytes (Myog+), which fuse and form new myofibers.
Nicolas A. Dumont et al. Development 2015;142:
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