1. T-Cell Receptor Gene Therapy: Critical Parameters for Clinical Success
Carsten Linnemann, Ton N.M. Schumacher, Gavin M. Bendle 
Journal of Investigative Dermatology 
Volume 131, Issue 9, Pages (September 2011)
DOI: /jid
Copyright © 2011 The Society for Investigative Dermatology, Inc Terms and Conditions

2. Figure 1
Milestones in the development of TCR gene therapy. NIH, National Institutes of Health; PBLs, peripheral blood lymphocytes; TCR, T-cell receptor.
Journal of Investigative Dermatology  , DOI: ( /jid )
Copyright © 2011 The Society for Investigative Dermatology, Inc Terms and Conditions

3. Figure 2
Formation of mixed-TCR dimers upon TCR gene transfer. The introduction of a new TCR into a T cell can lead to pairing of endogenous and introduced TCR chains. Theoretically, two new TCRs consisting of one endogenous and one introduced TCR chain can be formed. Problematically, the specificity of these mixed-TCR dimers cannot be predicted and may lead to autoreactivity. TCR, T-cell receptor.
Journal of Investigative Dermatology  , DOI: ( /jid )
Copyright © 2011 The Society for Investigative Dermatology, Inc Terms and Conditions

4. Figure 3
Potential future milestones in the clinical development of TCR gene therapy. TCR, T-cell receptor.
Journal of Investigative Dermatology  , DOI: ( /jid )
Copyright © 2011 The Society for Investigative Dermatology, Inc Terms and Conditions