1. The origins of organ-specific lymphatic vessels in the mouse embryo.
The origins of organ-specific lymphatic vessels in the mouse embryo. The embryonic origins of lymphatic vessels associated with the skin, heart and mesentery have recently been studied. Tie2-based lineage-tracing analyses in mice showed that ∼20% of skin LECs are not labeled by the transgene, suggesting a contribution from alternative, as yet undetermined, sources. In the mesentery, some LECs are of venous origin (labeled at E8.5 by the early EC marker Pdgfrβ), whereas others are derived from a non-venous source traced to the cKit lineage. Similarly, cardiac lymphatics are of mixed origins: some LECs are derived from venous ECs (Tie2 lineage), while an additional contribution from yolk sac-derived hemogenic endothelium cells (Vav1, Pdgfrb at E17.5 and Csf1r lineages) is also observed. Pdgfrβ is expressed early on in ECs (∼E8), whereas its expression is detected in mesenchymal cells at ∼E14.
Jonathan Semo et al. Development 2016;143:
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