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Figure 1. An outline of the novel ∼3

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1 Figure 1. An outline of the novel ∼3
Figure 1. An outline of the novel ∼3.7 kb Klebsiella genomic islet present at the KR116 and KR164 pheV loci with ... Figure 1. An outline of the novel ∼3.7 kb Klebsiella genomic islet present at the KR116 and KR164 pheV loci with predicted CDS and Blastp similarity hits. The grey rectangle highlights the full conserved domain of unknown function in the S. Typhi CT18 hypothetical protein homolog of KR116_pheV_4. UF, conserved upstream flank; DF, conserved downstream flank; DR, direct repeat; I, identity; E, expect value. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author Published by Oxford University Press.This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Bioscience Horizons, Volume 1, Issue 1, 01 March 2008, Pages 51–60, The content of this slide may be subject to copyright: please see the slide notes for details.

2 Figure 2. The genetic organization of the KR173 pheV locus genomic island and its associated Blast similarity hits in ... Figure 2. The genetic organization of the KR173 pheV locus genomic island and its associated Blast similarity hits in KR116 and S. Typhi CT18. UF, conserved upstream flank; DF, conserved downstream flank; DR, direct repeat; I, identity; E, expect value. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author Published by Oxford University Press.This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Bioscience Horizons, Volume 1, Issue 1, 01 March 2008, Pages 51–60, The content of this slide may be subject to copyright: please see the slide notes for details.

3 Figure 3. An illustration of genes present on the K
Figure 3. An illustration of genes present on the K. pneumoniae MGH78578 pheV island. The areas of the island that have ... Figure 3. An illustration of genes present on the K. pneumoniae MGH78578 pheV island. The areas of the island that have been confirmed to occur in KR162, KR163 and/or KR169 by sequence data and/or SGSP PCR restriction patterns are depicted at the top of the diagram. Details of the products encoded for by each of the labelled island genes are found in Table 2. The Yersinia frederiksenii ATC33641 Blastp homologs are pictured in the order that they appear on the genome; they are positioned in tandem and in the same order as in MGH However, in MGH78578 this structure is interrupted by KPN_03404 and KPN_ PapD<sub>1</sub>, PapD<sub>2</sub> and PapD<sub>3</sub> correspond to three distinct PapD proteins that share a high level of sequence similarity. UF, conserved upstream flank; DF, conserved downstream flank. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author Published by Oxford University Press.This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Bioscience Horizons, Volume 1, Issue 1, 01 March 2008, Pages 51–60, The content of this slide may be subject to copyright: please see the slide notes for details.

4 Figure 4. A diagram comparing the repeats present in the upstream and downstream extremities of elements present at the ... Figure 4. A diagram comparing the repeats present in the upstream and downstream extremities of elements present at the pheV locus in six Klebsiella strains. The full length repeat unit was identified to be a 163 bp sequence that started with 18 bp of the 3' end of pheV. Downstream repeats bore much nucleotide similarity to the repeat unit, although they were much shorter and occurred as isolated units. UR<sub>x</sub> indicates upstream direct repeat number x. DR<sub>x</sub> represents downstream direct repeat number x. The triangles represent the area of the direct repeat that corresponds to the 3' terminus of pheV. UF, conserved upstream flank; DF, conserved downstream flank. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author Published by Oxford University Press.This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Bioscience Horizons, Volume 1, Issue 1, 01 March 2008, Pages 51–60, The content of this slide may be subject to copyright: please see the slide notes for details.

5 Figure 5. A ClustalX alignment of all the direct repeats found at the pheV loci of six Klebsiella strains and ... Figure 5. A ClustalX alignment of all the direct repeats found at the pheV loci of six Klebsiella strains and illustrated in Fig. 4. Using KR116_UR1 as the reference unit, identical bases in other repeats were shaded grey. The alignment revealed that all upstream arm repeats in this panel of strains, except Kp342_UR3, exhibited limited nucleotide variation and were highly homologous. The repeats have been labelled STRAIN_URX or STRAIN_DRX, where URX denotes upstream direct repeat number X and DRX represents downstream direct repeat number X. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author Published by Oxford University Press.This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Bioscience Horizons, Volume 1, Issue 1, 01 March 2008, Pages 51–60, The content of this slide may be subject to copyright: please see the slide notes for details.

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