1. Volume 67, Issue 1, Pages 75-81 (January 2005)
The chemokine receptor 5 Δ32 mutation is associated with increased renal survival in patients with IgA nephropathy 
U.L.F. Panzer, Andr Schneider, Oliver M. Steinmetz, Ulrich Wenzel, Petra Barth, Rdiger Reinking, J.A.N. U. Becker, Sigrid Harendza, Gunther Zahner, Michael Fischereder, Bernhard H. Kramer, Detlef Schlondorff, Tammo Ostendorf, Jrgen Floege, U.D.O. Helmchen, Rolf A.K. Stahl, Rolf 
Kidney International 
Volume 67, Issue 1, Pages (January 2005)
DOI: /j x
Copyright © 2005 International Society of Nephrology Terms and Conditions

2. Figure 1
CCR5 genotype analysis. Example of genotype analysis to determine the presence of the CCR5 Δ32 mutation in patients with IgA nephropathy. The length of the amplified fragment is 215bp for the wild-type and 183bp for the CCR5 Δ32 allele. The polymerase chain reaction (PCR) fragments were separated on a 1.5% agarose gel and patients classified as wild-type (+/+), heterozygous (+/-), and homozygous (-/-) carrier.
Kidney International  , 75-81DOI: ( /j x)
Copyright © 2005 International Society of Nephrology Terms and Conditions

3. Figure 2
Influence of the CCR5 Δ32 genotype on renal survival in patients with IgA nephropathy. Kaplan-Meier plots of renal survival are shown in months from the date of biopsy until either end stage renal disease or the last follow up (CCR5 Δ32 genotype vs. wild-type, P < 0.001, Log-rank test).
Kidney International  , 75-81DOI: ( /j x)
Copyright © 2005 International Society of Nephrology Terms and Conditions

4. Figure 3
Functional effects of CCR5 Δ32 mutation on chemotaxis. RANTES (100ng/mL), MIP-1α (100ng/mL), MIP-1β (100ng/mL), and MCP-1 (100ng/mL) induced chemotaxis on freshly isolated monocytes was assessed in a chemotactic assay. The number of migrated M/M under basal conditions was standardized as 100%. Chemotaxis of monocytes toward all tested chemokines was significantly increased compared to basal conditions in all three groups with the exception of Δ32/Δ32 vs. basal in response to MIP-1β. Significance of differences between groups is indicated as follows: #P < 0.01+/+ vs. Δ32/Δ32; *P < 0.01+/+ vs. +/Δ32; †P < 0.01+/Δ32 vs. Δ32/Δ32.
Kidney International  , 75-81DOI: ( /j x)
Copyright © 2005 International Society of Nephrology Terms and Conditions