1. A 59-year-old womam with HPV− HNSCC (T2N0M0).
A 59-year-old womam with HPV− HNSCC (T2N0M0). A, T2-weighted image reveals a left tonsillar tumor (arrow) with intermediate signal intensity. B, B1000 and C, gray-scale ADC map show restricted tumor diffusion (arrows). The freehand ROI contoured on the ADC map is visible as a blue line. D, On the color-coded ADC map (same level as C), tumor heterogeneity (purple and various shades of blue-green areas within the tumor) is more easily appreciated than in C. E, Histology (hematoxylin-eosin; original magnification, 200X) shows heterogeneous tumor matrix with areas of densely packed and loosely packed squamous cells of variable size. Variable amounts of keratin pearls (asterisk) and necrosis were present in this tumor. F, Immunohistochemistry for p16 (original magnification, 200X) is negative (ie, most cells show no brownish coloration).
T. de Perrot et al. AJNR Am J Neuroradiol 2017;38:
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