1. Effect of PIs on insulin release by downstream insulin secretogogues.
Effect of PIs on insulin release by downstream insulin secretogogues. A: Insulin release from isolated mouse islets (10/well) was assayed in 1 mmol/l glucose with indinavir (20 μmol/l) or a glutamine/leucine mix (10 mmol/l each) alone or in combination. Bars represent mean ± SE of at least three separate experiments. For comparison, the inhibitory effect of indinavir (20 μmol/l) on glucose-induced insulin release (16.7 mmol/l) is shown. Data are representative of three independent experiments. Bars indicate mean ± SE of three to four assays per group. P values by Student’s t test. B: Insulin release from MIN6 cells was assayed in 16.7 mmol/l glucose with indinavir (20 μmol/l) or glibenclamide (1 μmol/l) alone or in combination. Bars represent mean ± SE of three separate experiments. P values by paired Student’s t test.
Joseph C. Koster et al. Diabetes 2003;52:
©2003 by American Diabetes Association