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Not all farming environments protect against the development of asthma and wheeze in children  Markus Johannes Ege, MD, Remo Frei, MSc, Christian Bieli,

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Presentation on theme: "Not all farming environments protect against the development of asthma and wheeze in children  Markus Johannes Ege, MD, Remo Frei, MSc, Christian Bieli,"— Presentation transcript:

1 Not all farming environments protect against the development of asthma and wheeze in children 
Markus Johannes Ege, MD, Remo Frei, MSc, Christian Bieli, MD, Dieneke Schram-Bijkerk, PhD, Marco Waser, PhD, Marcus R. Benz, MD, Gertraud Weiss, MPH, Fredrik Nyberg, MD, PhD, Marianne van Hage, MD, PhD, Göran Pershagen, MD, PhD, Bert Brunekreef, PhD, Josef Riedler, MD, Roger Lauener, MD, Charlotte Braun-Fahrländer, MD, Erika von Mutius, MD  Journal of Allergy and Clinical Immunology  Volume 119, Issue 5, Pages (May 2007) DOI: /j.jaci Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Farm-related specific determinants of asthma, wheeze, and atopic sensitization. Mutually adjusted ORs with 95% CIs additionally adjusted for sex, study center, group, and family history of asthma are shown. Atopic sensitization was adjusted for sex, study center, family history of atopy, and additionally for maternal exposure to animal sheds during pregnancy. The models were established by using backward elimination based on Akaike's information criterion. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Farm-related specific determinants for atopic and nonatopic asthma. Mutually adjusted ORs with 95% CIs additionally adjusted for number of older siblings, sex, study center and family history of asthma, where appropriate, are shown. The models were established by using backward elimination based on Akaike's information criterion in the subsample of children selected for measurement of allergen-specific IgE levels. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Effects of microbial compounds measured in mattress dust on asthma, wheeze, and atopic sensitization. Mutually adjusted ORs with 95% CIs additionally adjusted for all variables contributing to the respective models in Fig 1 are shown. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 4 Effect of being a farm child on asthma in agricultural and nonagricultural farms. Crude ORs are given with 95% CIs for asthma diagnosis dependent on being a farm child separately for the German subsample and the subsample of the 4 other countries. P values refer to Breslow-Day tests for homogeneity of effects. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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