1. Big Q: What role does DNA polymerase play in copying DNA?
DNA Replication
Big Q: What role does DNA polymerase play in copying DNA?
Big Q: How does DNA replication differ in prokaryotic cells and eukaryotic cells?

2. Engage - Why do we copy?
How can you make a copy of a page from the textbook?
Why is it important to make an exact copy?

3. Explore - A perfect Copy
Investigate the importance of making perfect copies
*** Answer questions on your Inquiry Warm-Up Worksheet

4. Explain - DNA Replication
Replication - DNA duplicates itself
This takes place during the S-phase of interphase

5. Elaborate -Making new DNA
Copying DNA
DNA starts as a double-stranded molecule
matching bases (A:T, C:G)
then it unzips…

6. Explain - How does it unzip?
Helicase - unwinds the double helix by breaking the hydrogen bonds between complimentary bases

7. Elaborate -DNA replication
Strands “unzip” at the weak bonds between bases

8. Elaborate -DNA replication
DNA bases in nucleus
Enzyme
DNA polymerase
adds new bases
proof reads DNA
DNA
polymerase

9. New copies of DNA Get 2 exact copies of DNA to split between new cells
Template Strand
DNA
polymerase
Complimentary Strand
DNA
polymerase

10. Explain - Telomeres
Telomeres - tips of eukaryotic chromosomes that help prevent DNA damage during replication
The enzyme telomerase adds telomeres to the chromosome
In cancer cells, these segments do not shut off

11. Explore - Prokaryotic DNA Replication
Proteins bind to DNA to trigger S phase
Starts at a single point
Proceeds in two direction until completion

12. Elaborate - Chapter Mystery UV Light
Investigate how DNA replication is related to cancer
***Answer questions on your question sheet

13. Evaluate - DNA Replication
Hand in your exit ticket upon exit