1. Supplementary Figure 3 Sequential Branch-off De novo * * * * **
Histology of the carcinoma
Invasive carcinoma
Supplementary Figure 3
Case 5
(16) H i * H
Case 6
(2) H * H
Case 1 H H
Case 2 H
Case 3
Annotation box
Sequential H
Gastric type
Intestinal type
Pancreatobiliary type
Oncocytic feature
Case 4 H i
Case 30 H L
Tubular adenocarcinoma
Mucinous adenocarcinoma
Case 7 H i i H, L, i,
IPMN with high-grade dysplasia
IPMN with low-grade dysplasia
Incipient IPMN
Case 26 H L
*, Second metachronous invasive cancer
**, Second synchronous invasive cancer
//, Margin of the first operation, recurrence case
(year), Time to recurrence
, Contiguous neoplastic lesion between IPMN and PDA via main pancreatic duct
Case 29 H L
Case 18 L
Case 13 L L L i
KRAS WT
GNAS WT
G12V
R201H
Case 12 L L i
G12D
R201C
G12R
Q227H
Case 21
(2) H * H i
Q61H/Q61R
G12C
Case 25
A142T
Branch-off L
Case 8
TP53
Mutation
Aberrant L
SMAD4
Mutation
Aberrant
CDKN2A/p16
Mutation
Aberrant
Case 11 L i
CTNNB1 mutation and/or β-catenin nuclear stain
RNF43 mutation and/or loss
Case 14 L L
Other mutations
Case 16 L
(Example)
TP53
CDKN2A/p16
SMAD4
Case 19
Mutation L
IHC
Case 24 H L L
GNAS
Case 23
(1) H L *
KRAS
Case 17 L i
Case 15 L i
Case 10
De novo L
Case 22 L
Case 28 ** L i
Case 20
(4) i H L i
(10)
Case 27 H i H H
Case 9 H
IPMN subtype 1 2 3 4 5 6 7 8 9 10
Distance from invasive cancer (cm)