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Claire Quinn, M. Sc. , Edward Ryan, M. D. , E. Anne Claessens, M. D

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Presentation on theme: "Claire Quinn, M. Sc. , Edward Ryan, M. D. , E. Anne Claessens, M. D"— Presentation transcript:

1 The presence of pinopodes in the human endometrium does not delineate the implantation window 
Claire Quinn, M.Sc., Edward Ryan, M.D., E. Anne Claessens, M.D., Ellen Greenblatt, M.D., Peter Hawrylyshyn, M.D., Barbara Cruickshank, M.D., Thomas Hannam, M.D., Caroline Dunk, Ph.D., Robert F. Casper, M.D.  Fertility and Sterility  Volume 87, Issue 5, Pages (May 2007) DOI: /j.fertnstert Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

2 FIGURE 1 SEM picture of the apical surface of the human endometrium. Borders (valleys) can be seen around individual cells. (A) Absence of pinopodes. Microvilli and cilia can be seen extending from the surface of individual cells. (B) Three pinopodes with smooth surfaces can be seen. Scale bars: (A) = 5 μm, (B) = 5 μm. Quinn. Pinopodes in the human endometrium. Fertil Steril 2007. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

3 FIGURE 2 Day of the menstrual cycle (LH days seen in boxes under graph) verses pinopode score in infertile patients. (A) Each green bar in the graph represents a patient that gave only one biopsy. Other colored bars represent patients that gave ≥2 biopsies during one cycle (one color/patient). Bars with a square above them (three bars/three different patients) represent patients who went on to become pregnant in a subsequent cycle. (B) SEM pictures of pinopodes from patients on LH + 4, LH + 8, LH + 11, and LH Scale bars, upper row = 20 μm, lower row = 5 μm. Quinn. Pinopodes in the human endometrium. Fertil Steril 2007. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

4 FIGURE 3 Day of the menstrual cycle verses pinopode score in regularly cycling fertile patients. (A) Numbers in bar graph indicate specific patients. (B) Pinopodes in an endometrial sample taken on LH day 0 from a fertile patient (patient #46). Scale bars (i) = 20 μm, (ii) = 10 μm. Quinn. Pinopodes in the human endometrium. Fertil Steril 2007. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

5 FIGURE 4 Pinopodes detected in a patient administered depot leuprolide acetate followed by 24 days of micronized estradiol and norethindrone addback. Scale bars: (A) = 10 μm, (B) = 5 μm. Quinn. Pinopodes in the human endometrium. Fertil Steril 2007. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

6 FIGURE 5 Pinopodes detected in endometrial tissue dissected out following elective termination of pregnancy performed between weeks 5 and 11 of gestation. (A) Bar graph of pinopode scores. (B) SEM pictures of endometrial tissue collected from week 7 of gestation. Scale bars: (i) = 20 μm, (ii) = 10 μm. Quinn. Pinopodes in the human endometrium. Fertil Steril 2007. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions


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