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A glomerulus from a patient who developed nephrotic syndrome while receiving a nonsteroidal anti-inflammatory drug for arthritis. A glomerulus from a patient who developed nephrotic syndrome while receiving a nonsteroidal anti-inflammatory drug for arthritis. The glomerulus exhibits global thickening of the glomerular basement with spike formation, which is characteristic of stage 2 membranous changes. Jones methenamine silver, ×400. Jonathan J. Hogan et al. CJASN 2015;10: ©2015 by American Society of Nephrology
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