1. Morphologic findings from serial biopsies.
Morphologic findings from serial biopsies. (A–E) The initial biopsy was performed 10 months post-transplant and the specimen showed (A) focal collapsing lesions characterized by retraction of the tuft and epithelial cell hypertrophy and hyperplasia (Jones methenamine silver stain; original magnification, ×400); (B) FSGS (Masson trichrome stain; original magnification, ×400); (C) peritubular capillaritis (periodic acid–Schiff stain; original magnification, ×400); (D) minimal foot process effacement (Unstained; original magnification ×4000); and (E) multilamination of glomerular basement membranes (arrow, unstained; original magnification ×12,000). (F) The second biopsy was performed at 12 months post-transplant and the specimen continued to show collapsing lesions (Jones methenamine silver stain; original magnification, ×400).
Randolph A. Hennigar, and Christina L. Klein CJASN 2017;12:
©2017 by American Society of Nephrology