1. The complex field of interplay between vasoactive agents
Pernille B. Hansen 
Kidney International 
Volume 76, Issue 9, Pages (November 2009)
DOI: /ki
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2. Figure 1
Interaction between α-adrenoceptors and angiotensin II receptors. Stimulation of α-adrenoceptors by norepinephrine (NE) leads to increased calcium sensitivity in the afferent arteriole through phosphorylation of myosin phosphatase target subunit 1 (MYPT1). This inhibits myosin light chain phosphatase (MLCP) activity and increases the level of phosphorylated myosin light chain (MLC), increasing the contractility and calcium sensitivity of the afferent arteriole in response to angiotensin II (Ang II). This could potentially occur through a phospholipase C (PLC)-dependent and Rho kinase–dependent pathway. CaM, calmodulin; IP3, inositol triphosphate; MLCK, myosin light chain kinase; PP1c, type 1 protein phosphatase; VSMC, vascular smooth-muscle cell.
Kidney International  , DOI: ( /ki )
Copyright © 2009 International Society of Nephrology Terms and Conditions