1. OTX2 transfers into supporting cells of neurogenic niches.
OTX2 transfers into supporting cells of neurogenic niches. A, In dorsal V-SVZ, OTX2 staining is detected in some GFAP-labeled astrocytes but not in DCX-labeled neuroblasts. Arrowheads highlight astrocytes containing OTX2. B, Along the lateral ventricular wall, OTX2 staining is detected in vimentin (VIM)-labeled ependymal cells. C, In the RMS, OTX2 staining is detected in GFAP-labeled astrocytes but not in DCX-labeled neuroblasts. Arrowheads highlight astrocytes containing OTX2. D, Orthogonal projection shows OTX2 in the nucleus of astrocytes within the RMS.
Anabelle Planques et al. eNeuro 2019;6:ENEURO
©2019 by Society for Neuroscience