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Alterations in exon 4 of the p53 gene in gastric carcinoma

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Presentation on theme: "Alterations in exon 4 of the p53 gene in gastric carcinoma"— Presentation transcript:

1 Alterations in exon 4 of the p53 gene in gastric carcinoma
Tara Shepherd, Dawn Tolbert, Jacqueline Benedetti, John Macdonald, Grant Stemmermann, Jonathan Wiest, Gary DeVoe, Mary Ann Miller, Jiang Wang, Amy Noffsinger, Cecilia Fenoglio–Preiser  Gastroenterology  Volume 118, Issue 6, Pages (June 2000) DOI: /S (00) Copyright © 2000 American Gastroenterological Association Terms and Conditions

2 Fig. 1 Diagrammatic representation of exon 4 showing a transcriptional activation region (TAR) at aa 32-42, a phosphorylation site at aa 33 (small p) , an adenovirus E1b protein binding site, a DNA-specific binding domain at aa , and a structural domain at aa The stars indicate the location of the 7 mutations. The capital P indicates 2 polymorphic sites. Gastroenterology  , DOI: ( /S (00) ) Copyright © 2000 American Gastroenterological Association Terms and Conditions

3 Fig. 2 Examples of 2 of the mutations that were present. (A) Insertion of a C (arrow). (B) C→T mutation. Gastroenterology  , DOI: ( /S (00) ) Copyright © 2000 American Gastroenterological Association Terms and Conditions

4 Fig. 3 The 3 codon 72 genotypes. (A) Homozygous CGC encoding arginine. (B) Heterozygous arginine/proline with one allele of CGC and the other CCC. (C) Homozygous CCC encoding proline. Gastroenterology  , DOI: ( /S (00) ) Copyright © 2000 American Gastroenterological Association Terms and Conditions


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