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Mammalian Variations on a Theme: A Smo and Sufu Surprise

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Presentation on theme: "Mammalian Variations on a Theme: A Smo and Sufu Surprise"— Presentation transcript:

1 Mammalian Variations on a Theme: A Smo and Sufu Surprise
Anthony E. Oro  Developmental Cell  Volume 10, Issue 2, Pages (February 2006) DOI: /j.devcel Copyright © 2006 Elsevier Inc. Terms and Conditions

2 Figure 1 Proposed Mechanism of How Smo Controls the Formation of Repressor and Activator Forms of Gli/Ci in Drosophila and Mammals In mammals, components of the primary cilia such as IFT88 or KIF3a fill an analogous role as Cos2. Sufu functions are unclear but may regulate Gli processing or as a corepressor. Filled black circles are known phosphorylation events that regulate protein activity, while open black circles are proposed events. Developmental Cell  , DOI: ( /j.devcel ) Copyright © 2006 Elsevier Inc. Terms and Conditions

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