1. Gene profiling reveals increased expression of uteroglobin and other anti-inflammatory genes in glucocorticoid-treated nasal polyps 
Mikael Benson, MD, PhD, Lena Carlsson, MD, PhD, Mikael Adner, PhD, Margareta Jernås, BSc, Mats Rudemo, PhD, Anders Sjögren, BSc, Per Arne Svensson, PhD, Rolf Uddman, MD, PhD, Lars Olaf Cardell, MD, PhD 
Journal of Allergy and Clinical Immunology 
Volume 113, Issue 6, Pages (June 2004)
DOI: /j.jaci
Copyright © 2004 American Academy of Allergy, Asthma and Immunology Terms and Conditions

2. Fig 1
Expression levels of genes previously described as downregulated15 by GCs in nasal polyps before and after treatment with a local GC. The diagonal line is the line of identity. Ten of the 30 genes differed less than 10% (circles), and of the remaining 20, 2 had a higher (open boxes) and 18 had a lower (filled boxes) expression after treatment (P = .001, Wilcoxon signed-rank test). CCL, Chemokine (C-C motif) ligand; ICAM1, intercellular adhesion molecule 1 (CD54), human rhinovirus receptor; IFNG, IFN-γ; JAK2, Janus kinase 2 (a protein tyrosine kinase); MCP, monocyte chemotactic protein; MMP, matrix metalloproteinase 12; MUC2, mucin 2, intestinal, tracheal; NOS2A, nitric oxide synthase 2A, inducible, hepatocytes; PLA2G6, phospholipase A2, group VI, cytosolic, calcium independent; PLAT, plasminogen activator, tissue; PTGS2, prostaglandin-endoperoxide synthase 2; SELE, selectin E (endothelial adhesion molecule 1); SELL, selectin L (lymphocyte adhesion molecule 1); STAT, signal transducer and activator of transcription 1, 91 kd; TCR, T-cell receptor; TNF, tumor necrosis factor (TNF superfamily, member 2); VCAM1, vascular cell adhesion molecule 1.
Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )
Copyright © 2004 American Academy of Allergy, Asthma and Immunology Terms and Conditions

3. Fig 2
Mean ± SEM expression levels of mammaglobin B (A) and uteroglobin (B) in nasal polyps (open bars) and nasal biopsy specimens (filled bars) from healthy control subjects and in various control human cells and tissues. The expression levels in nasal polyps are derived from experiments with HuGeU133A Gene Chips and the other expression levels from experiments with HuGe95A GeneChips. ND, Not detectable; AT, adipose tissue; SC, subcutaneous.
Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )
Copyright © 2004 American Academy of Allergy, Asthma and Immunology Terms and Conditions

4. Fig 3
Expression of uteroglobin protein determined by means of immunohistochemistry in the nasal mucosa from one representative healthy control subject (A and B) and from one nasal polyp (C and D) at 200× magnification. Immunoreactivity for uteroglobin is found in the epithelium (Fig 3, A) and in the acini of seromucous glands (Fig 3, B). In nasal polyps uteroglobin immunofluorescence is found in the epithelium (Fig 3, C) and in glandular acini (Fig 3, D).
Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )
Copyright © 2004 American Academy of Allergy, Asthma and Immunology Terms and Conditions